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Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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35 hot topic(s) found with the query "Preterm birth"

Mediating Factors in the Association of Maternal Educational Level With Pregnancy Outcomes: A Mendelian Randomization Study.
Tormod Rogne et al. JAMA Netw Open 2024 1 (1) e2351166 (Posted: Jan 12, 2024 6AM)

From the abstract: " Which pathways mediate the inequity in pregnancy health associated with low educational attainment? In this cohort study of more than 3 million individuals, an association between genetically estimated lower educational attainment and increased risk of ectopic pregnancy, hyperemesis gravidarum, gestational diabetes, preeclampsia, preterm birth, and offspring low birth weight was observed. A sizeable portion of these associations were explained by targetable risk factors. These findings suggest that the association of socioeconomic inequalities with adverse pregnancy outcomes may be reduced by intervening for type 2 diabetes, body mass index, smoking, high-density lipoprotein cholesterol level, and systolic blood pressure."

Missed Cystic Fibrosis Newborn Screening Cases due to Immunoreactive Trypsinogen Levels below Program Cutoffs: A National Survey of Risk Factors
M Kharrazi et al, IJNS, October 27, 2022 (Posted: Oct 31, 2022 9AM)

This survey aimed to find factors associated with missed CF cases due to IRT levels below program cutoffs. Twenty-nine states responded to a U.S-wide survey and 13 supplied program-related data for low IRT false screen negative cases (CFFN) and CF true screen positive cases (CFTP) for analysis. Factors associated with “low” CFFN subgroup were older age at specimen collection, Saturday birth, hotter season of newborn dried blood spot collection, maximum = 3 days laboratories could be closed, preterm birth, and formula feeding newborns. Lowering IRT cutoffs may reduce “high” IRT CFFNs. Addressing hospital and laboratory factors may reduce “low” IRT CFFNs.

Association of SARS-CoV-2 Vaccination During Pregnancy With Pregnancy Outcomes
MC Magnus et al, JAMA, March 24, 2022 (Posted: Mar 27, 2022 7AM)

Is SARS-CoV-2 vaccination during pregnancy associated with adverse pregnancy outcomes? In this population-based retrospective cohort study that included 157 521 deliveries in Sweden and Norway, SARS-CoV-2 vaccination during pregnancy, compared with no SARS-CoV-2 vaccination during pregnancy, was not significantly associated with risk of preterm birth (adjusted hazard ratio [aHR], 0.98), stillbirth (aHR, 0.86), small for gestational age (adjusted odds ratio [aOR], 0.97), low Apgar score (aOR, 0.97), or neonatal care admission (aOR, 0.97).

Receipt of COVID-19 Vaccine During Pregnancy and Preterm or Small-for-Gestational-Age at Birth — Eight Integrated Health Care Organizations, United States, December 15, 2020–July 22, 2021
HS Lipkind et al, MMWR, January 4, 2022 (Posted: Jan 04, 2022 2PM)

Pregnant women with COVID-19 are at increased risk for severe illness and adverse birth outcomes, yet many remain reluctant to be vaccinated. In a retrospective cohort of >40,000 pregnant women, COVID-19 vaccination during pregnancy was not associated with preterm birth or small-for-gestational-age at birth overall, stratified by trimester of vaccination, or number of vaccine doses received during pregnancy, compared with unvaccinated pregnant women.

Development and validation of a risk prediction model of preterm birth for women with preterm labour symptoms (the QUIDS study): A prospective cohort study and individual participant data meta-analysis.
Stock Sarah J et al. PLoS medicine 2021 7 (7) e1003686 (Posted: Jul 14, 2021 7AM)

In this study, we found that a risk prediction model including vaginal fFN concentration and clinical risk factors showed promising performance in the prediction of spontaneous preterm birth within 7 days of test and has potential to inform management decisions for women with threatened preterm labor. Further evaluation of the risk prediction model in clinical practice is required to determine whether the risk prediction model improves clinical outcomes if used in practice.

Preliminary Findings of mRNA Covid-19 Vaccine Safety in Pregnant Persons
TT Shimabukuru et al, NEJM< June 17, 2021 (Posted: Jun 16, 2021 7PM)

Among 3958 participants enrolled in the v-safe pregnancy registry, 827 had a completed pregnancy, of which 115 (13.9%) resulted in a pregnancy loss and 712 (86.1%) resulted in a live birth (mostly among participants with vaccination in the third trimester). Adverse neonatal outcomes included preterm birth (in 9.4%) and small size for gestational age (in 3.2%); no neonatal deaths were reported.

Spontaneous preterm birth: the underpinnings in the maternal and fetal genomes
E Bhattacharjee et al, NPJ Genomic Medicine, June 2021 (Posted: Jun 13, 2021 7AM)

Preterm birth (PTB) is a major cause of neonatal mortality and health complications in infants. Elucidation of its genetic underpinnings can lead to improved understanding of the biological mechanisms and boost the development of methods to predict PTB. Although recent genome-based studies of both mother and fetus have identified several genetic loci which might be implicated in PTB, these results suffer from a lack of consistency across multiple studies and populations.

Multiomics Characterization of Preterm Birth in Low- and Middle-Income Countries
F Jehan et al, JAMA Network Open, December 18, 2020 (Posted: Dec 19, 2020 7AM)

this diagnostic/prognostic study of 81 pregnant women from 5 birth cohorts in low- and middle-income countries, several correlates of preterm birth in urine and blood were found to be associated with PTB. Although cohort-specific signatures were present, a machine learning algorithm generated a model that was capable of predicting PTB across the cohorts.

Investigating the Impact of COVID-19 during Pregnancy
CDC, October 9, 2020 (Posted: Oct 10, 2020 7AM)

Based on what is known at this time, pregnant people might be at an increased risk for severe illness from COVID-19 compared to non-pregnant people. Additionally, pregnant people with COVID-19 might have an increased risk of adverse pregnancy outcomes, such as preterm birth.

Meta-Analysis of Vaginal Microbiome Data Provides New Insights Into Preterm Birth
I Kosti et al, Front Micro, April 8, 2020 (Posted: Apr 08, 2020 3PM)

We integrated raw longitudinal 16S rRNA vaginal microbiome data from five independent studies across 3,201 samples and were able to gain new insights into the vaginal microbiome state in women who deliver preterm. We found that women who deliver prematurely show higher within-sample variance in vaginal microbiome abundance, mostly during the first trimester.

Deep Learning Predicts Extreme Preterm Birth from Electronic Health Records.
Gao Cheng et al. Journal of biomedical informatics 2019 Oct 103334 (Posted: Nov 06, 2019 8AM)

Models for predicting preterm birth generally have focused on very preterm (28-32 weeks) and moderate to late preterm (32-37 weeks) settings. However, extreme preterm birth, before the 28th week accounts for the majority of newborn deaths. We investigated the extent to which deep learning models based on electronic health records can predict EPB.

Noninvasive blood tests for fetal development predict gestational age and preterm delivery.
Ngo Thuy T M et al. Science (New York, N.Y.) 2018 06 (6393) 1133-1136 (Posted: Jun 14, 2019 9AM)

The vaginal microbiome and preterm birth
J Fettweis et al, Nature Medicine, May 29, 2019 (Posted: May 29, 2019 3PM)

Genomic and molecular characterization of preterm birth
TA Knijenberg et al, PNAS, February 4, 2019 (Posted: Mar 05, 2019 9AM)

Enabling precision medicine in neonatology, an integrated repository for preterm birth research.
Sirota Marina et al. Scientific data 2018 Nov 5180219 (Posted: Nov 07, 2018 11AM)

Premature Birth
Risk factors for preterm birth include delivering a premature baby in the past, November 2018 Brand (Posted: Nov 06, 2018 3PM)

Blood Test Might Predict Pregnancy Due Date and Preterm Birth
P Belluck, New York Times, June 7, 2018 (Posted: Jun 08, 2018 8AM)

Spontaneous Preterm Birth: Advances Toward the Discovery of Genetic Predisposition.
Strauss Jerome F et al. American journal of obstetrics and gynecology 2017 Dec (Posted: Jan 15, 2018 5PM)

Six Genes May Hold Clues to Preterm Birth
Genome Magazine, Oct 2017 (Posted: Nov 06, 2017 5AM)

Genetics, hormonal influences, and pretertm birth.
Rood Kara M et al. Seminars in perinatology 2017 Sep (Posted: Oct 18, 2017 6PM)

Genetic Associations with Gestational Duration and Spontaneous Preterm Birth
G Zhang et al, NEJM, Sep 20, 2017 (Posted: Sep 20, 2017 6PM)

Six Genes Linked With Preterm Births
M Fox, NBC News, Sep 6, 2017 (Posted: Sep 06, 2017 6PM)

The significance of genetics in pathophysiologic models of premature birth.
Uberos Jose et al. Minerva pediatrica 2017 May (Posted: Sep 06, 2017 6PM)

Applying Precision Public Health to Prevent Preterm Birth.
Newnham John P et al. Frontiers in public health 2017 66 (Posted: May 07, 2017 1PM)

Insights into genetic susceptibility in the etiology of spontaneous preterm birth.
Parets Sasha E et al. The application of clinical genetics 2015 283-90 (Posted: Nov 02, 2016 10AM)

Factors associated with preterm birth include prior preterm birth
Brand (Posted: Nov 02, 2016 10AM)

Public Health Grand Rounds: Strategies to Prevent Preterm Birth
Brand (Posted: Nov 12, 2015 2PM)

Preterm Birth
Brand (Posted: Nov 04, 2015 5PM)

The idiopathic preterm delivery methylation profile in umbilical cord blood DNA.
Fernando Febilla et al. BMC genomics 2015 (1) 736 (Posted: Nov 03, 2015 4PM)

What is the basis for a genetic approach in neonatal disorders?
Bhandari Vineet et al. Seminars in perinatology 2015 Oct (Posted: Nov 03, 2015 4PM)

Genomics in the neonatal nursery: Focus on ROP.
Hartnett Mary Elizabeth et al. Seminars in perinatology 2015 Oct (Posted: Nov 03, 2015 4PM)

The genetics of preterm birth: Progress and promise.
Monangi Nagendra K et al. Seminars in perinatology 2015 Oct (Posted: Nov 03, 2015 4PM)

Another Frontier in Microbiome Research: Preterm Birth
JA Jacob, JAMA September 29, 2015 (Posted: Sep 29, 2015 1PM)

High-Resolution Metabolomics: Review of the Field and Implications for Nursing Science and the Study of Preterm Birth.
Li Shuzhao et al. Biol Res Nurs 2015 Jul 16. (Posted: Aug 17, 2015 6PM)

Exploration of preterm birth rates using the public health exposome database and computational analysis methods.
Kershenbaum Anne D et al. Int J Environ Res Public Health 2014 Dec (12) 12346-66 (Posted: May 20, 2015 2PM)


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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